H.R. 6552 would reauthorize several programs that prevent trafficking in persons, which are managed by the Departments of Justice (DOJ), Health and Human Services (HHS), Homeland Security (DHS), and State, and the U.S. Agency for International Development. The bill would authorize the appropriation of $1.1 billion over the 2022-2026 period for those purposes. In addition, the bill would require the General Services Administration (GSA) to implement a new contractual preference for hotels and motels with a policy of zero-tolerance for human trafficking. In total, CBO estimates that implementing the bill would cost $553 million over the 2022-2027 period. Such spending would be subject to appropriation of the specified and estimated amounts.