S. 4171 would authorize the appropriation of $502 million over the 2023-2026 period for programs to prevent trafficking in persons. Those amounts would be authorized for accounts managed by the Department of State, Department of Justice (DOJ), Department of Homeland Security (DHS), and the U.S. Agency for International Development. CBO estimates that implementing S. 4171 would cost $271 million over the 2022-2027 period, subject to the appropriation of the specified amounts.