S. 3891 would authorize the annual appropriation of $250 million over the 2021-2025 period for the National Institute of Standards and Technology (NIST) to establish an artificial intelligence (AI) research program. The bill also would direct the National Science Foundation (NSF) to designate up to six centers for AI research and, subject to the availability of appropriations, to obligate up to $50 million annually over the same period for each center. Finally, S. 3891 would authorize the appropriation of such sums as may be necessary for the NSF to award grants and scholarships to increase enrollment in AI degree programs.