S. 4488 would establish an interagency committee to assess the risk of global catastrophes that could harm or destroy human civilization. The bill would require the President to develop a strategy based on the committee’s recommendations to respond to such risks and require the Department of Homeland Security to lead an exercise to test the strategy. CBO estimates that enacting S. 4488 would have no effect on direct spending and an insignificant effect on revenues over the 2023-2032 period. CBO has not estimated the discretionary costs of implementing the bill. The bill contains no intergovernmental or private-sector mandates as defined in the Unfunded Mandates Reform Act.